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Kui Chen

Name: Kui Chen

Title: Associate Professor

Start Year at LSUS: 2008

Department: Chemistry/Physics Department

Office Location: Science Building 326

Office Phone: 318-797-5133

Email: kui.chen@lsus.edu

Office Hours:

Tuesdays and Thursdays: 10:45 ~ 12:15

Wednesdays: noon ~ 2:00

Fridays: 9:00 ~ 10:00

Teaching Assignments:

CHEM 121 - General Chemistry I

CHEM 124 - General Chemistry II

CHEM 124L - General Chemistry II Lab

CHEM 255 - Analytical Chemistry

CHEM 255L - Analytical Chemistry Lab

CHEM 456 - Instrumental Analysis

CHEM 456L - Instrumental Analysis Lab

Research Interests:  

 A common theme of my research is the integration of novel metallic nanoparticles as a multi-functional platform in the design of innovative sensor and imaging agents. The primary goal is to develop nanomaterials for biomedical and bioanalytical applications and understand the chemical interactions of these nanomaterials with their surrounding. Advances in nanofabrication in recent years have yielded metallic nanoparticles with unique optical and physical properties. Incorporation of these unique properties could potentially lead to new sensing and imaging paradigms with enhanced sensitivity, resolution and the ability to probe biological systems at the molecular and cellular levels. In addition, the small size and versatile surface functionalization schemes available for metallic nanoparticles make them well-suited for in vivo studies and biomedical applications. The surface of the metallic nanoparticles will be functionalized with a bio-recognition element for targeted delivery and an optically-encoding chromophore. Two optical detection modalities, surface-enhanced Raman scattering (SERS) and plasmon-enhanced fluorescence, will be employed. They are chosen due to their inherent high sensitivity and non-invasive nature.

The on-going projects in the lab include: 1) Develop plasmon-enhanced fluorescent nanosensors for probing the roles of reactive oxygen species (ROS) and oxidative stress in aging and age-related diseases. Chemo-selective fluorescent ROS probes based on non-oxidative mechanism will be designed and synthesized for selective detection of individual ROS species. Plasmon-enhanced fluorescence by metallic nanostructures will be used as an enhancement strategy for the detection of ROS at physiologically-relevant sensitivity. 2) Investigate the use of gold-nanoshell-mediated hyperthermia targeting lymphatic endothelial cells as a minimally invasive strategy for inhibiting tumor metastasis. Au nanoshells (AuNSs) are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near Infrared (NIR) region and efficiently convert absorbed light to heat. NIR-absorbing AuNSs will be delivered to lymphatic vessels and regional lymph nodes where a therapeutic dose of heat is generated upon laser irradiation and induces photothermal injury to lymphatic endothelial cells. The working hypothesis is tumor metastasis will be suppressed when photothermal injury to lymphatic endothelial cells (LECs) disrupts tumor-associated lymphatic vessels and inhibits lymphangiogenesis.

Selected Publications:

1.      G. Grant, J. Li, Y. Zhang, S. Li, C. Wilson, K. Chen, T. Vo-Dinh, Q. Liu, "Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics", Journal of Biomedical optics, 2011, 16(3), 037004

2.      K. Chen, T. Vo-Dinh, "Single Molecule Detection and Activity Monitoring at the Nanoscale Level in Fixed and Living Cells by Optical Spectroscopy", Book Chapter, in: Nanotechnology in Biology and Medicine - Methods, Devices, and Applications, Vo-Dinh T. (ed.), CRC Press, Boca Raton, FL. 16-1 (2007)

3.      K. Chen, M. Leona, T. Vo-Dinh, "Surface-Enhanced Raman Scattering for Identification of Organic Pigments and Dyes in Works of Art and Cultural Heritage Material", Sensor Review, 2007, 27, 109

4.      Q. Liu, K. Chen, M. E. Martin, A. Wintenberg, R. Lenarduzzi, M. Panjehpour, B. F. Overholt, and T. Vo-Dinh "Development of a synchronous fluorescence imaging system and data analysis methods", Optics Express, 2007, 15, 12583

5.      K. Chen, M. Leona, K-C. Vo-Dinh, F. Yan, M. B. Wabuyele, T. Vo-Dinh, "Application of surface-enhanced Raman scattering (SERS) for the identification of anthraquinone dyes used in works of art", Journal of Raman Spectroscopy, 2006, 37, 520

6.      M. E. Martin, M. B. Wabuyele, K. Chen, P. M. Kasili, M. Panjehpour, M. Phan, B. Overholt, G. Cunningham, D. Wilson, R. C. DeNovo, and T. Vo-Dinh, "Development of an Advanced Hyperspectral Imaging (HSI)System with Applications for Cancer Detection", Annals of Biomedical Engineering, 2006, 34, 1061